Fast Optimization of Temperature Focusing in Hyperthermia Treatment of Sub-Superficial Tumors

Microwave hyperthermia aims at selectively heating cancer cells to a supra-physiological temperature. For non-superficial tumors, this can be achieved by means of an antenna array equipped with proper cooling system (the water bolus) avoid overheating the skin. In patient-specific treatment planning, feedings are optimized maximize specific absorption rate (SAR) inside tumor, or directly temperature there, involving higher numerical cost. We present here method effect low-complexity temperature-based planning. It arises from recognizing that SAR and have shifted peaks due thermal boundary conditions bolus for physiological effects like air flow in respiratory ducts. our method, focusing on tumor is via SAR-based optimization excitations, but optimizing its target account effects. The process turned into finding peak position maximizes chosen objective function. Application 3D head neck region provides coverage consistently better than obtained SAR-optimization alone, also considering uncertainties parameters. This improvement solving bioheat equation reduced number times, avoiding inclusion global process.